杜克大学生物医学工程系招聘博士后，坐标坐标北卡罗来纳

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Postdoctoral Fellows in Heart and Muscle Disease Modeling and Regeneration

The Bursac lab performs basic and translational studies in the fields of skeletal and cardiac muscle biology, disease, and regeneration (published inNature Communications,Science Advances,Cell Stem Cell,Nature,PNAS,Circulation Research,Biomaterials, etc.). Complex three-dimensional organoids (engineered

tissues) are made from human iPSC-derived cardiomyocytes, myogenic, endothelial, neuronal, and immune system cells. In these 3D culture systems, genome editing (CRISPR/Cas9), next-generation sequencing, and various physiological and biochemical techniques are applied to model and study human diseases (e.g., Duchenne Muscular Dystrophy, Pompe disease, Dysferlinopathy, cardiac arrhythmias) and discover new therapeutics. The most promising gene and drug therapeutic candidates from in vitro studies are tested in animal models of myocardial infarction, skeletal muscle injury, and genetic diseases in vivo. We use both small (mice, rats) and large (pig) animals to perform basic and pre-clinical gene and cell therapy studies.

Qualified candidates should have a PhD or MD degree in cell and molecular biology, biomedical engineering, or other relevant areas of biomedical sciences. Candidates with experience in differentiation of human iPS cells into cardiomyocytes or skeletal muscle cells, genome editing, and in vivo models of cardiac and skeletal muscle diseases will be given priority. The Bursac group is a diverse and stimulating environment that performs cutting-edge interdisciplinary research in collaboration with cell biologists and clinicians at Duke University. The available resources and combination of basic and translational research provide an exceptional training environment for pursuit of academic career. Postdoctoral fellows are expected to be self-motivated, good communicators, and able to work both independently and as a part of a larger group. An important goal of the work will be to publish in high-impact journals and generate preliminary results for career awards (e.g. K99) as well as other types of funding. Significant emphasis during postdoctoral training will be placed on grant and manuscript writing and mentoring of graduate students. Duke University is an equal opportunity employer.

Dr. Nenad Bursac is a Professor of Biomedical Engineering, Cell Biology, and Medicine at Duke University and one of world leaders in the areas of heart and skeletal muscle bioengineering. During his PhD and postdoctoral work at MIT and Johns Hopkins University, he developed first engineered mammalian heart tissues and methods to study cardiac arrhythmias in a dish. Currently, Dr. Bursac"s research involves design of high-fidelity human microphysiological

systems to study pathophysiology of striated muscles in vitro and development of novel cell- and gene-based therapies for cardiac and skeletal muscle regeneration in vivo. Dr. Bursac has authored over 120 publications and has mentored over 60 trainees. He is a recipient of the Stansell Family Distinguished Research Award and Stem Cell Innovation Award, a fellow of AIMBE and BMES, and an Associate Editor of Science Advances. The work from Bursac lab has been published in prestigious journals such asNature,Cell Stem Cell,Circulation,Circulation research,PNAS,Nature Communications,Science Advance,Nature Protocols,Biomaterials, andElife. His group provides excellent training environment for the state of art techniques in human pluripotent stem cell differentiation, CRISPR-Cas gene editing, fabrication of organ-on-chip microphysiological systems, and in vivo animal studies of regeneration. Dr. Bursac is well-funded by NIH with multiple on-going R01s. Numerous trainees from the Bursac lab have received training grants/fellowships from NIH, NSF, and American Heart Association.